Research

The Center for Research in Transplantation and Translational Immunology (CR2TI)

Pr. Régis Josien, Director
Dr. Sophie Brouard, Deputy-Director

The Center for Research in Transplantation and Translational Immunology (CR2TI) is a joint research unit (UMR 1064) affiliated to INSERM and Nantes Université and located at CHU Nantes and IRS2. We develop basic, translational and clinical research programs to improve knowledge, diagnosis and treatments in the context of organ and cell transplantation (Axis 1), inflammatory and autoimmune diseases (Axis 2) and infectious diseases (Axis 3). Our main goals are to: 1) Characterize the pathogenic or protective immune responses involved in these diseases in order to identify new therapeutic targets; 2) Transfer these advances to the clinic by developing new immunotherapeutic and diagnostic approaches; 3) Develop alternative strategies for the replacement or repair of organs / tissues through a better understanding of the developmental biology of cells and organisms (Axis 4). The CR2TI is made up of independent teams that bring together scientists and clinicians with complementary expertise in immunology, transplantation, autoimmunity, infectious diseases, nephrology, intensive care, developmental biology and genomics. The CR2TI is part of the "Immunotherapy graft oncology (IGO)" Laboratory of Excellence.